A Graphical User Interface is a man-machine interface device, in which objects to handle are drawn as icons on the screen, so the user can send controls by by a pointing device, usually a mouse or a keyboard. It is always easy and require less skills to operate a device from a visual representations of the workspace (GUI) by simply clicking a mouse or using a keyboard rather than a command line. In this article we are going to design a Graphical User Interface using Microsoft Visual C#. This software could be installed in any computer running windows operating systems. The computer will connect to the microcontroller using an RS232 serial cable. The PIC microcontroller will receive commands from the computer to control devices connected to it such as motors, LEDs etc.