The I2C debugger is not needed in hardware unless for troubleshooting purposes you would want to analyse the I2C packets. It’s only required there for simulation. You can also remove it in simulation but you’ll have to change the I2C pull-up resistors model types from analog to digital.
Right-click the I2C resistors, Edit Properties, Change Model Type form Analog to Digital. Then the simulation will also work without the I2C debugger.